Slow computer troubleshooting

Here's the list of things I do when troubleshooting a slow computer:

1) Run a malwarebytes scan and remove anything found
2) Install all applicable driver updates
3) Run "sfc /scannow" from an elevated command prompt
4) Install all applicable Windows updates
5) Install all applicable Office updates, if installed separately (true for some versions of Office 2016)
6) Check amount of free disk space (ideally at least 20 GB free)
7) Check for adware/crapware that is installed.  Remove by normal add/remove programs
8) Check CPU usage and disk usage for conditions above 99%

mnh.winnermore.info adware removal

In Chrome on a client computer, each time she'd open a window, you could see the browser looking to the site mnh.winnermore.info for content.  This included when she'd click to reply to a message within her Exchange webmail.  There was no program in add/remove programs.  There were no extensions in Chrome.  Malwarebytes, rkill, adwcleaner, and all other cleaners I use found nothing.
This problem persisted in even a new Chrome user profile (same Windows profile).  I even searched through the registry and found nothing.  Eventually, I came across this site:
http://greatis.com/blog/adware/remove-mnh-winnermore-net.htm

Per the page above, the fix was to set Chome to default settings.  This worked.  I don't know how/why, but somehow this site embeds itself somewhere I couldn't find it at all.